The harmonica was developed in Europe in the early 19th century. In 1857 a clockmaker named Mathias Hohner started producing harmonicas. The Hohner name is the most well known today in making the instrument. Shortly after he began making them, he shipped some to emigrants living in the United States. Abraham Lincoln reportedly carried a harmonica in his pocket.
In the 1950s, harmonicas were used to play the blues.
This is my favorite. Runaround from Blues Travelers